The “Magic” that Saved Jimmy Kimmel’s Son Made Possible by Animal Research

https://fbresearch.org/animal-research-helped-jimmy-kimmels-son/

City Xpress is proud to be a part of this ever evolving research community that relies on the safe and stressful transport of research animals.

Many research experts tell us each week that the consistent temperature, sanitized environment and especially the ground transport of their research animals enables them to successfully proceed with their research. 

By keeping the research animals grounded stress is reduced on the research animals that can contribute to skewing the results of the valuable test results.

City Xpress transports mice from NIH, NCI, FDA and every university, research organization both private and government, on the east coast.

City Xpress has transported research mice covering distances of twenty miles to six thousand miles in the safest contained environment taking into consideration temperature, sanitized interior and all of these pertinent factors are monitored and transmitted to the customer in real time.

City Xpress is the leader in live research animal GROUND TRANSPORT.

Transporting Rodents and Transporting Rabbits to and from Research Laboratories ::::: Animal Transportation Safety

Background on Animal Transportation Safety

The microbiological status (health status) of animals can have a profound effect on research results and should therefore be carefully monitored and controlled. One of the greatest means for potential cross contamination of pathogens is during transportation and use of animals in investigator laboratories for experimental procedures. This policy describes procedures investigators must follow in order to minimize cross contamination during transport between animal facilities and investigator laboratories. The procedures also minimize allergen exposure to personnel working with and in proximity to animals.  City Xpress uses Vimoba to sanitize its vehicles prior to transport of live research animals.  Vimoba properties mimic the MB10 solution that is used in you vivariums but has a less caustic effect on the fiberglass interiors of all City Xpress vans.

Transportation is a possible source of contamination in animal facilities.  It is also a possible source of animal allergen exposure for the human population. In order to safeguard both animals and humans working in laboratories, precautions must be taken. In addition, transporting research animals through public spaces may draw unwanted attention to the research animals, the animal facility, the laboratory where procedures are carried out, and the researchers carrying out the work. It is essential that all personnel transporting animals do not draw attention to the animals being transported and that the transport is conducted in a campus-approved manner.

Use of Temperature Controlled Vehicle or Climate Controlled Vehicle

Rodents are to be transported in filter-topped cages. All animals must be transported in a temperature controlled vehicle using a secondary barrier to minimize the transfer of allergens or other health hazards into the vehicle used for transport (e.g., impermeable plastic sheet to go over vehicle upholstery [cannot be used to cover the animal cage]), a disposable absorbent pad, lab bench paper, a plastic tub, a clean Tyvek lab coat). For rodents, filter tops must be secured on the cage for transport using lab tape or equivalent. Transport must occur in a temperature controlled vehicle with a minimum number of stops; a cart may be used in place of a vehicle for very short distances only in mild weather and the cages must be appropriately covered (using a laboratory coat, cloth, fabric drape, or similar items for covering the cages without inhibiting air flow) to avoid drawing attention to the animals. A university-owned vehicle is preferred for transport but a privately owned vehicle is allowed for rodent/rabbit/cat transport. Plastic bags must never be used to cover cages/containers during transport because they restrict air flow and place the animals at risk.  Some vivaria do not allow in and out traffic of animals it is essential to check with the facility manager/technician-in-charge regarding each specific situation. Please also see the Attending Veterinarian's Standard of Care (http://safetyservices.ucdavis.edu/sites/default/files/documents/SC-20-108.pdf) regarding research animal transportation. Guinea pigs, rabbits and cats do not require filter top caging for transport as it is not standard housing for these species. They can be transported in secure pet carriers ensuring the animals are contained and allergen exposure is minimized. Taping filter paper or other breathable barrier over the air holes of the containers and following the above barrier instructions will further reduce allergen exposure of personnel and minimize contamination of the transport vehicle.

Animal Transport Procedures

• Ensure you are allowed to remove and return animals from the vivarium.
• Ensure the procedure/laboratory space is listed on the Animal Care Protocol before moving any animals.
• Due to possible cross-contamination, ensure movement between the housing area, procedure/laboratory space and any other procedure space has been approved by the Health Monitoring Coordinator (animaltransfer@ucdavis.edu ).
• Rodent cage/transport container dimensions are determined based on the number and weight of the animals and comparable to their normal housing cage size.
• Rodents may not be overcrowded for transport to laboratories or procedure space.
• For example 8 mice many not be placed into a cage designed to house 4-5 animals.
• Rodent cages must be fitted with a filter top for transport and taped in place. When pet carriers are used, open air access holes of the pet carrier must covered with breathable material.
• Use a fresh cage or wipe down the exterior of the cage to minimize the transfer or allergens to common areas or the transport vehicle.  Terminal transport boxes may be available for rodents, see your vivarium manager for details.
• Standard micro-isolator cages will have the water bottle flipped and then the top securely affixed with tape.
• Some Individually Ventilated Caging (IVC) bottles are external to the tops thus they must be turned after the top is affixed.
• Hydropac pouches can be left in place, they typically do not drip when moved and will leak if removed.
• Cage cards remain affixed to the cage and must accompany the animals.
• Do not put cards inside the cages as the animals may destroy them.
• Once the filter top or filter paper is taped to the top of the cage the animals can be covered for transport with breathable fabric or a paper covering dedicated for animal use only.
• The visual barrier covering the transport container/rodent cage must be clean, sanitizable or disposable and may not be taken into the animal facility. It may not be stored in the vehicle as it may be contaminated with allergens.

Animal Transportation Temperature Guidelines

• When the transport event is complete, anything contacting the transport container or rodent cage must be removed from the vehicle.
• A cart may be used for very short distances during temperate weather only.
• Animals can be extremely sensitive to hot and cold temperatures.
• Temperature controlled vehicle must be used in hot or cold or rainy weather and/or when in populated areas where carrying or carting them would draw attention to the animals or the animal facility.
• A laboratory coat, lab bench paper, or other barrier must be placed between the cages/pet carrier and the upholstery or floor.  Use a seat belt or other means to secure the carriers as necessary.  Placing them on the floor will also stabilize the transport enclosure.
• Animals should not be transported in the trunk or non-climate controlled area of a vehicle, or the bed of a pickup. Exceptions may be permitted for field study animals if described in a protocol that is approved by the IACUC. Temperature, season, and time of day must be considered to minimize animal welfare concerns.
• Smoking, eating, or drinking when animals are in the vehicle is not permitted.
• During research animal transportation, unnecessary stops are not permitted (i.e., drive-through at a bank or restaurant). Animal transport must be direct from the housing area to the facility they are being transported to. Animals must never be left unattended in a vehicle.
• When using a personal vehicle to transport animals, non-university affiliated individuals must not be in the vehicle during transport.

The vehicle's climate control must be used as needed to maintain the temperature comfortable for the animals

• A bicycle cannot be used for transport.
• F.  When animals arrive in the laboratory or other approved destination: Filter tops must remain in place at all times, except when the animals are being removed from or returned to cages. Filter tops are removed and animals are handled in laboratories or other approved areas only. Animals may not be taken into eating areas, restrooms, common areas, office areas, or other non-laboratory/non-animal use space.
• Manipulation in a biosafety cabinet is strongly preferred, with the understanding that not all manipulations can be performed in a biosafety cabinet or hood.
• Laminar flow/clean benches (i.e., clean benches that direct HEPA-filtered air from back to front across the bench and thus directly toward the lab worker) are not appropriate for rodent manipulations as they can disperse allergens directly towards personnel.
• Return must be accomplished as described in the transport procedures above.
• Each vivarium will have a preferred method of reintroduction of animals and caging into the vivarium.
• This may involve the disinfection of the outside of the cages and possibly fresh caging for the rodents.
• See your vivarium or your facility manager for the appropriate mehtods.

References - Animal Transport Safety

Procedure: IACUC-13
Date: October 20, 2016
Enabled by: USDA/PHS
Supersedes: May 16, 2013
Think Safe. Act Safe. Be Safe.

Interesting Chart

Interesting chart above.

Although City Xpress did not arrive until 1987, It wasn't until 2006 that City Xpress made its first delivery of a research mouse from Johns Hopkins to the NIH

City Xpress arrived in a temperature regulated van to pick up the shipment and the temperature in the van was monitored to register 68 degrees during the entire transport of the research mice.

Since that first transport City Xpress has acquired the largest fleet of TCVs(Temperature Controlled Vehicle) with the added benefits of CC (climate capture) which is temperature data captured for any portion of your trip, real time vehicle location, and specially trained drivers to ensure a safe delivery evry time.

Neural Mechanism Links Alcohol Consumption to Binge Eating

http://www.the-scientist.com/?articles.view/articleNo/47964/title/Neural-Mechanism-Links-Alcohol-Consumption-to-Binge-Eating/

This interesting and groundbreaking article was discovered by City Xpress and we felt it was worthy of passing on to our readership.

We have always felt at City Xpress we perform a very small part in our meticulous process of transporting these valuable research mice    in a very tight strict climate and antispetic environment.

According to researchers studying mice, excessive alcohol consumption can trigger over eating in humans.

Mice were injected with alcohol and separated from the control mice that were injected with a saline solution.

They were separated o avoid group behavior

Both male and female mice over ate within a four hour period

Oliver Smithies, Technologist Behind Knockout Mice, Dies

Oliver Smithies, Technologist Behind Knockout Mice, Dies

The technologist, Oliver Smithes who developed tools that could “knock out” specific genetic components in model organisms, died on January 10, 2017 at the age of 91.

Termed the “knock out” mouse, this altered species were valuable to researchers all over the world.

When asked to transport these highly valuable mice in our temperature regulated and temperature monitored climate controlled vans, we always take extra precautions when transporting these highly valuable mice.

Smithes also invented starch gel electrophoresis for the development of gene targeting enabling researchers to create thousands of strains of gentetically atered mice.

When utilizing City Xpress’ transport services these researchers may wish to pinpoint the location of these valuable mice at any time of the journey.  The researchers find the auto location ability valuable when using City Xpress to transport their mice.

Smithes worked late in his career at the  University of Toronto’s Connaught Medical Research Laboratory in a group effort to purify insulin.